英文名称
英文别名
Heterogeneous nuclear ribonucleoprotein I; Heterogeneous Nuclear Ribonucleoprotein Polypeptide I; hnRNP I; HNRNPI; HNRPI; MGC10830; MGC8461; Polypyrimidine Tract Binding Protein 1; Polypyrimidine tract binding protein; Polypyrimidine tract-binding protein 1; pPTB; PTB 1; PTB 2; PTB 3; PTB 4; PTB; PTB T; PTB1; PTB2; PTB3; PTB4; PTBP 1; PTBP1; PTBP1_HUMAN; PTBT; RNA Binding Protein; 57 kDa RNA binding protein PPTB 1; 57 kDa RNA binding protein PPTB1; 57 kDa RNA-binding protein PPTB-1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
| WB | Human | Mouse, Rat, Pig, Sheep, Cow, more... | 1:500-2000 |
| IHC-P | Human, Rat | Mouse, Pig, Sheep, Cow, Chicken, more... | 1:100-500 |
| IHC-F | Human, Rat | Mouse, Pig, Sheep, Cow, Chicken, more... | 1:100-500 |
| IF | Human, Rat | Mouse, Pig, Sheep, Cow, Chicken, more... | 1:100-500 |
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
交叉反应
Human, Rat (predicted: Mouse, Pig, Sheep, Cow, Chicken, Dog, Horse)
免疫原
KLH conjugated synthetic peptide derived from human PTBP1 : 451-531/531
纯化方法
affinity purified by Protein A
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding
Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing
Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing
亚基
Contains 4 RRM (RNA recognition motif) domains.
相似性
Contains 4 RRM (RNA recognition motif) domains.
功能
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
