细胞表面趋化因子受体10抗体-上海雅吉生物科技有限公司

规格	价格	库存
50ul	￥ 1280	1

英文名称

CCR10 Rabbit pAb

中文名称

细胞表面趋化因子受体10抗体

英文别名

C-C chemokine receptor 10; C C chemokine receptor type 10; C C CKR 10; CC chemokine receptor 10; CC CKR 10; CCR 10; CCR-10; CCR10; Chemokine(C C motif) receptor 10; G protein coupled receptor 2; G protein-coupled receptor 2; GPR 2; GPR2.

产品应用

IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=5μg/Test

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

交叉反应

Human, Mouse (predicted: Rat, Rabbit, Pig, Cow, Dog)

抗体来源

Rabbit

免疫原

KLH conjugated synthetic peptide derived from human CCR-10: 1-52/362

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Polyclonal

理论分子量

40 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

亚细胞定位

Cell membrane; Multi-pass membrane protein.

组织特异性

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.

相似性

Belongs to the G-protein coupled receptor 1 family.

SWISS

P46092

Gene ID

2826

功能

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 2826 Human

Entrez Gene : 12777 Mouse

Omim : 600240 Human

SwissProt : P46092 Human

SwissProt : Q9JL21 Mouse

Unigene : 278446 Human

Unigene : 103813 Mouse

Unigene : 8021 Mouse

背景资料

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

应用	推荐稀释比例
IHC-P	1:100-500
IHC-F	1:100-500
IF	1:100-500
Flow-Cyt	5μg/Test

Paraformaldehyde-fixed, paraffin embedded (mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCR10) Polyclonal Antibody, Unconjugated (bs-1710R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) instructionsand DAB staining.

Blank control: 293FT(blue)
Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:100 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 5μl in 100 μL1X PBS containing 0.5% BSA(green).

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