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胃蛋白酶原C单克隆抗体
产品名称:
胃蛋白酶原C单克隆抗体
英文名称:
PGII
型号:
V4201
产品库存
1
产品价格
电议

产品详情

产品编号V4201
英文名称PGII
中文名称胃蛋白酶原C单克隆抗体
别????名PEPC_HUMAN; Gastricsin; EC:3.4.23.3; Pepsinogen C; PEPC; PGC; progastricsin;??
克?隆?号3D5
理论分子量42kDa
细胞定位分泌型蛋白?
性????状Lyophilized or Liquid
缓?冲?液PBS (ph=7.4)
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq].

Function:
Hydrolyzes a variety of proteins.

Subcellular Location:
Secreted.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
P20142

Gene ID:
5225

Database links:

Entrez Gene: 5225 Human

Entrez Gene: 24864 Rat

Omim: 169740 Human

SwissProt: P20142 Human

SwissProt: P04073 Rat

Unigene: 1867 Human

Unigene: 9735 Rat



胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病变易感性的关系。

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