产品分类/PRODUCT CLASSIFICATION
| 产品编号 | V3702 |
| 英文名称 | Interleukin-1 receptor-like 1/ST2 |
| 中文名称 | 白细胞介素1受体相关蛋白单克隆抗体 |
| 别????名 | DER-4; DER4; FIT 1; Growth stimulation expressed gene 2; homolog of mouse growth stimulation-expressed; Il1rl1; IL33R; ILRL1_HUMAN; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Ly84; Lymphocyte antigen 84; Protein ST2; ST2; ST2L; ST2V; Ste2; Suppressor of tumorigenicity 2; T1; T1 protein.?? |
| 克?隆?号 | 1E12 |
| 理论分子量 | 61kDa |
| 细胞定位 | 细胞膜?分泌型蛋白? |
| 性????状 | Liquid |
| 缓?冲?液 | 0.01M PBS(pH7.4) |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP. Function: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Subunit: Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Subcellular Location: Isoform C: Cell membrane. Isoform B: Secreted. Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. SWISS: Q01638 Gene ID: 9173 Database links: Entrez Gene: 9173?Human Entrez Gene: 17082?Mouse Omim: 601203?Human SwissProt: Q01638?Human SwissProt: P14719?Mouse Unigene: 66?Human Unigene: 289824?Mouse |
