产品分类/PRODUCT CLASSIFICATION
| 产品编号 | W2401 |
| 英文名称 | Ferritin Light Chain |
| 中文名称 | 铁蛋白轻链抗体 |
| 别????名 | Ferritin light polypeptide; Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; MGC71996; NBIA 3; NBIA3.?? |
| 理论分子量 | 20kDa |
| 细胞定位 | 细胞浆?细胞外基质?分泌型蛋白? |
| 性????状 | Liquid |
| 缓?冲?液 | 0.01M PBS(pH7.4) |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]. Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Subunit: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Iron enters the spherical protein shell through pores that are formed between subunits. Mutations leading to truncation or the addition of extra residues at the C-terminus interfere with normal pore formation and with iron accumulation. DISEASE: Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Similarity: Belongs to the ferritin family. Contains 1 ferritin-like diiron domain. SWISS: P02792 Gene ID: 2512 Database links: Entrez Gene: 2512?Human Entrez Gene: 14325?Mouse Omim: 134790?Human SwissProt: P02792?Human SwissProt: P29391?Mouse Unigene: 433670?Human Unigene: 713706?Human Unigene: 30357?Mouse Unigene: 431913?Mouse Unigene: 1905?Rat? |
| 产品图片 |  Measured by its binding ability in a indirect ELISA. Immobilized Human FTL, His Tag (Cat. bs-41189P) at 2 μg/mL (100 μL/well) can bind Anti-Human PSA monoclonal antibody, the minimum detection concentration is 0.05ng/mL |
