上海细胞库
人源细胞系| 稳转细胞系| 基因敲除株| 基因点突变细胞株| 基因过表达细胞株| 重组细胞系| 猪的细胞系| 马细胞系| 兔的细胞系| 犬的细胞系| 山羊的细胞系| 鱼的细胞系| 猴的细胞系| 仓鼠的细胞系| 狗的细胞系| 牛的细胞| 大鼠细胞系| 小鼠细胞系| 其他细胞系|
人源细胞系| 稳转细胞系| 基因敲除株| 基因点突变细胞株| 基因过表达细胞株| 重组细胞系| 猪的细胞系| 马细胞系| 兔的细胞系| 犬的细胞系| 山羊的细胞系| 鱼的细胞系| 猴的细胞系| 仓鼠的细胞系| 狗的细胞系| 牛的细胞| 大鼠细胞系| 小鼠细胞系| 其他细胞系|
| 规格 | 价格 | 库存 |
|---|---|---|
| 500ug | ￥ 800.00 | 10 |
| 产品编号 | bs-11422P |
| 英文名称 | NPS Antibody Blocking Peptide |
| 中文名称 | 神经肽S封闭多肽 |
| 别????名 | NeuropeptideS; Neuropeptide-S; Neuropeptide S; NPS; NPS_HUMAN.??NULL |
| 性????状 | Lyophilized powder |
| 物????种 | human |
| 序????列 | NPS(70-89aa) |
| 纯化方法 | HPLC |
| 活性 | Not tested |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | Neuropeptides are regulators of synaptic transmission and their effects are mediated by G-protein coupled receptors. NPS (Neuropeptide S) is a 20 amino acid peptide cleaved from a larger precursor that contains a hydrophobic signal peptide and proteolytic cleavage processing sites. The N-terminal residue of NPS is always a serine regardless of the species. NPS is predominantly found in the central nervous system and plays an important role regulating sleep/wake functions, locomotion, arousal/anxiety responses and food intake. NPS functions by binding and activating its receptor, NPSR, and increasing intracellular calcium levels thereby acting as an excitatory transmitter. In addition, NPS stimulates the hypothalamo-pituitary adrenal (HPA) axis via the release of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP). NPS and its receptor NPSR may also play a role in asthma pathogenesis. SWISS: P0C0P6 Gene ID: 594857 神经肽S(Neuropeptide S)是2002年发现的生物活性肽,具有促觉醒、抗焦虑和增强记忆力的作用。NPS前体1nRNA主要表达在一系列脑区,包括蓝斑核、Barrington核以及臂旁外侧核和脑干中的三叉神经感觉主核等,还包括杏仁核、背内侧核以及下丘脑中。而NPS受体(NPSR)则在脑区中具有广泛和高水平的表达。NPSR在基底神经节中有大量表达,NPSR这一部分在自主运动调节中起着十分重要的作用。 |
