首页 > 抗体蛋白 > 蛋白多肽
纤溶酶原激活物抑制因子封闭多肽
产品名称:
纤溶酶原激活物抑制因子封闭多肽
英文名称:
SERPINE1 Antibody Blocking Peptide
产品类别:
蛋白多肽
产品编号:
bs-1704P
保存条件:
Shipped at 4℃. Stored at -20℃ for one year. Avoid
[价格]
规格 价格 库存
500ug ¥ 800.00 10

产品详情

产品编号bs-1704P
英文名称SERPINE1 Antibody Blocking Peptide
中文名称纤溶酶原激活物抑制因子封闭多肽
别????名Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin E1; Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin peptidase inhibitor clade E; Serpine 1; Serpine1.??
性????状Lyophilized powder
物????种human
纯化方法HPLC
活性Not tested
保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.

SWISS:
P05121

Gene ID:
5054

PAI-1是一种单链糖蛋白,其生理作用很多:
(1)与组织型纤溶酶原激活物(tissue plasminogen activator,t-PA)形成1:1的复合物而使t-PA失活;
(2)保护基底膜不被血浆来源的酶所降解;
(3)保护细胞间的接触面而维持组织结构的完整性;
(4)在结缔组织演变、凝血、纤溶、补体激活和炎症反应等过程中具有抑制蛋白降解作用;
(5)在细胞周期中,PAI-1转录水平的变化及其在细胞内的积聚,对细胞形态的维持、细胞与其间质的粘附、细胞增殖、信号转导及基因表达等都有重要意义;

联系我们

TEL:021-34661275  点击拨打热线