上海细胞库
人源细胞系| 稳转细胞系| 基因敲除株| 基因点突变细胞株| 基因过表达细胞株| 重组细胞系| 猪的细胞系| 马细胞系| 兔的细胞系| 犬的细胞系| 山羊的细胞系| 鱼的细胞系| 猴的细胞系| 仓鼠的细胞系| 狗的细胞系| 牛的细胞| 大鼠细胞系| 小鼠细胞系| 其他细胞系|
人源细胞系| 稳转细胞系| 基因敲除株| 基因点突变细胞株| 基因过表达细胞株| 重组细胞系| 猪的细胞系| 马细胞系| 兔的细胞系| 犬的细胞系| 山羊的细胞系| 鱼的细胞系| 猴的细胞系| 仓鼠的细胞系| 狗的细胞系| 牛的细胞| 大鼠细胞系| 小鼠细胞系| 其他细胞系|
| 规格 | 价格 | 库存 |
|---|---|---|
| 500ug | ￥ 1500.00 | 10 |
| 1mg | ￥ 2500.00 | 10 |
| 产品编号 | Y-0198P |
| 英文名称 | Nogo-66 1-40 (NEP 1-40) Peptide |
| 中文名称 | Nogo-66 (1-40)多肽 |
| 别????名 | Nogo-66(1-40) antagonist peptide; NEP 1-40 peptide; Reticulon-4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5.?? |
| 理论分子量 | 4.622kDa |
| 性????状 | Lyophilized powder |
| 物????种 | human |
| 序????列 | Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide, MW: 4622.35 |
| 纯化方法 | HPLC |
| 活性 | Yes |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 | Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent. Sequence: Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35 活性多肽：Nogo-66 NEP1-40，能促进神经细胞轴突再生；Nogo-66的末端片断能促进脊髓损伤动物模型神经轴突的再生，并改善功能恢复。 Nogo-A的再生活性片段Nogo-66具有明显的诱导神经干细胞向胶质细胞分化的作用，Nogo-66的胶质分化诱导作用是通过NgR介导的。 氨基酸序列：Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35） |
