产品分类/PRODUCT CLASSIFICATION
| 规格 | 价格 | 库存 |
|---|---|---|
| 100ug | ￥ 800.00 | 10 |
| 500ug | ￥ 3000.00 | 10 |
| 产品编号 | bs-0954P |
| 英文名称 | EDN1 Acitive Peptide |
| 中文名称 | 内皮素-1封闭多肽 |
| 别????名 | Endothelin-1; Big endothelin 1; EDN 1; EDN1; EDN1 protein; Endothelin1; ET 1; ET1; OTTHUMP00000039245; PPET1; Preproendothelin 1; Preproendothelin1; CAS: 117399-94-7??内皮素1; Endothelin-1 (human, porcine) 内皮素-1,人,猪; |
 | Specific References??(1)?????|?????bs-0954P has been referenced in 1 publications. [IF=6.785]?Tian B et al. Electrochemical Immunoassay of Endothelin-1 Based on a Fenton-Type Reaction Using Cu(II)-Containing Nanocomposites as NanozymesAnal Chem.2020 Dec 15;92(24):15916-15926.??other?;?? |
| 检测分子量 | 2491.9 |
| 性????状 | Lyophilized powder |
| 物????种 | human |
| 序????列 | CSCSSLMDKECVYFCHLDIIW (Disulfide bridges C1-C15, C3-C11) |
| 纯化方法 | HPLC |
| 活性 | Yes |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 | Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Molecular weight: 2491.9 Molecular formula: C109H159N25O32S5 CAS: 117399-94-7 MDL: MFCD00133305 Reconstitution: 1mM (1mg/0.4013mL) SWISS: P05305 Gene ID: 1906 Endothelin-1 (human, porcine)多肽内皮素家族的三种异肽之一，是由活化的内皮细胞合成和分泌的，是一种具有强大血管收缩活性的肽，人和猪内皮素1序列同源，是有效的内源性血管收缩剂。Endothelin-1通过两种类型受体ETA和ETB发挥作用。Endothelin-1诱导缺氧诱导因子1α血管内皮生长因子的产生。除了血管收缩作用外，ET-1还会导致血管细胞纤维化，刺激活性氧的产生。研究显示，ET-1诱导促炎机制，增加超氧阴离子的产生和细胞因子的分泌。它还可由心肌细胞释放。它是活化或功能异常的内皮细胞的一种标志物。 |
