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重组人乳腺癌易感基因2蛋白
产品名称:
重组人乳腺癌易感基因2蛋白
英文名称:
Recombinant human BRCA2 protein, His
产品类别:
蛋白多肽
产品编号:
bs-42161P
保存条件:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw
[价格]
规格 价格 库存
100ug ¥ 2980.00 10
500ug ¥ 9500.00 10

产品详情

产品编号bs-42161P
英文名称Recombinant human BRCA2 protein, His
中文名称重组人乳腺癌易感基因2蛋白
别????名BRCA 1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1. ??
理论分子量22.8kDa
性????状Lyophilized or Liquid
浓????度>0.5mg/ml
物????种Human
序????列210-392/3418
纯????度>90% as determined by SDS-PAGE
表达系统E.coli
标签N-His
缓?冲?液20mM Tris (pH8.0)
保存条件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

SWISS:
P38398

Gene ID:
672

产品图片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.

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