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重组人组织相容性复合体蛋白
产品名称:
重组人组织相容性复合体蛋白
英文名称:
Recombinant human HLA-A & Beta-2-MG Heterodimer protein, His&Avi (HEK293)
产品类别:
蛋白多肽
产品编号:
bs-43159P
保存条件:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw
[价格]
规格 价格 库存
100ug ¥ 4800.00 10
500ug ¥ 15000.00 10

产品详情

产品编号bs-43159P
英文名称Recombinant human HLA-A & Beta-2-MG Heterodimer protein, His&Avi (HEK293)
中文名称重组人组织相容性复合体蛋白
别????名Major Histocompatibility Complex, Class I; HLA Class I Histocompatibility Antigen, A Alpha Chain; HLAA; HLA Class I Histocompatibility Antigen, A-1 Alpha Chain; MHC Class I Antigen HLA-A Heavy Chain; Leukocyte Antigen Class I-A; Human Leukocyte Antigen A; HLAA_HUMAN.??
理论分子量35.5kDa
性????状Lyophilized or Liquid
浓????度>0.5mg/ml
物????种Human
纯????度>90% as determined by SDS-PAGE
内毒素Not analyzed
表达系统HEK293 cell
活性Not tested
标签C-His&Avi
缓?冲?液PBS (pH=7.4)
保存条件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]

SWISS:
P04439

Gene ID:
3105

产品图片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.

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