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重组人肢体畸形相关蛋白FMN1
产品名称:
重组人肢体畸形相关蛋白FMN1
英文名称:
Recombinant human FMN1 protein, His
产品类别:
蛋白多肽
产品编号:
bs-42131P
保存条件:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw
[价格]
规格 价格 库存
100ug ¥ 2980.00 10
500ug ¥ 9500.00 10

产品详情

产品编号bs-42131P
英文名称Recombinant human FMN1 protein, His
中文名称重组人肢体畸形相关蛋白FMN1
别????名FMN; Formin 1; Formin1; Formin-1; LD; Limb deformity protein homolog; FMN1_HUMAN.??
理论分子量41.4kDa
性????状Lyophilized or Liquid
浓????度>1mg/ml
物????种Human
序????列1-354/1419
纯????度>90% as determined by SDS-PAGE
内毒素Not analyzed
活性Not tested
标签N-His
缓?冲?液20mM Tris (pH=8.0) with 2M Urea
保存条件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively.

SWISS:
Q68DA7

Gene ID:
342184

产品图片
The purity of the protein is greater than 83% as determined by reducing SDS-PAGE.

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