规格 | 价格 | 库存 |
---|---|---|
100ug | ¥ 4880.00 | 10 |
500ug | ¥ 15800.00 | 10 |
产品编号 | bs-43562P |
英文名称 | Recombinant human TNFRSF14 protein, C-His (HEK293) |
中文名称 | 重组人TNFRSF14蛋白 |
别????名 | HVEM; Tumor necrosis factor receptor superfamily member 14; HveA1; Tumor necrosis factor receptor-like 2; TR21; CD270; Herpesvirus entry mediator A; TNR14_HUMAN. Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen); CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; UNQ329/PRO509?? |
理论分子量 | 18.4kDa |
性????状 | Lyophilized or Liquid |
浓????度 | >0.72mg/ml |
物????种 | Human |
序????列 | 39-202/283 |
纯????度 | >90% as determined by SDS-PAGE |
纯化方法 | AC |
内毒素 | Not analyzed |
表达系统 | HEK293 cell |
活性 | Not tested |
标签 | C-His |
缓?冲?液 | PBS (pH=7.4) |
保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 | TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. SWISS: Q92956 Gene ID: 8764 |
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