英文名称：Recombinant human CEACAM5 protein, C-His (HEK293)

中文名称：重组人癌胚抗原蛋白

英文别名：Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5; CD66e; CD66e antigen; CEACAM5; CEAM5_HUMAN; DKFZp781M2392; Meconium antigen 100.

性状：Lyophilized or Liquid

纯化方法：AC

理论分子量：72

浓度：>1.0mg/ml

储存液：PBS (pH7.4).

研究领域：

Cancer > Tumor biomarkers > Tumor antigens

Cancer > Tumor immunology > Tumor-associated antigens

Stem Cells > Mesenchymal Stem Cells > Surface Molecules

Tags & Cell Markers > Cell Type Markers > Tumor Associated

序列：35-685/702

标签：C-His

纯度：> 90% as determined by SDS-PAGE

内毒素：Not analyzed

表达系统：HEK293 cell

复溶：Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

保存条件：Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

注意事项：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 1048 Human

Omim : 114890 Human

SwissProt : P06731 Human

Unigene : 709196 Human

The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.

背景资料

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

CEA (Carcino Embryonic Antigen, CD66e) is synthesized during development in the fetal gut, and re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEA is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). CEA is a member of a large family of glycoproteins, a useful tumor marker for adenocarcinoma, and found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. CEA was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, CEA was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

基因名：CEACAM5

蛋白名：Carcinoembryonic antigen-related cell adhesion molecule 6

亚基：Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

亚细胞定位：Cell membrane; Lipid-anchor, GPI-anchor

组织特异：Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

翻译后修饰：Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

相似性：Belongs to the immunoglobulin superfamily. CEA family.

功能：Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.重组人癌胚抗原蛋白