规格 | 价格 | 库存 |
---|---|---|
100ug | ¥ 4800.00 | 10 |
500ug | ¥ 15000.00 | 10 |
产品编号 | bs-43122P |
英文名称 | Recombinant human Noggin protein (HEK293) |
中文名称 | 重组人指(趾)关节粘连NOG蛋白 |
别????名 | NOG; SYM 1; SYM1; Symphalangism 1 (proximal); Synostoses (multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN?? |
理论分子量 | 23kDa |
性????状 | Lyophilized or Liquid |
浓????度 | >0.5 mg/ml |
物????种 | Human |
序????列 | 28-232/232 |
纯????度 | > 90% as determined by SDS PAGE |
纯化方法 | AC |
内毒素 | Not analyzed |
表达系统 | HEK293 cell |
活性 | Not tested |
标签 | Tag Free |
缓?冲?液 | PBS (pH=7.4) |
保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 | Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. SWISS: Q13253 Gene ID: 9241 |
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