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重组人指(趾)关节粘连NOG蛋白
产品名称:
重组人指(趾)关节粘连NOG蛋白
英文名称:
Recombinant human Noggin protein (HEK293)
产品类别:
蛋白多肽
产品编号:
bs-43122P
保存条件:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw
[价格]
规格 价格 库存
100ug ¥ 4800.00 10
500ug ¥ 15000.00 10

产品详情

产品编号bs-43122P
英文名称Recombinant human Noggin protein (HEK293)
中文名称重组人指(趾)关节粘连NOG蛋白
别????名NOG; SYM 1; SYM1; Symphalangism 1 (proximal); Synostoses (multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN??
理论分子量23kDa
性????状Lyophilized or Liquid
浓????度>0.5 mg/ml
物????种Human
序????列28-232/232
纯????度> 90% as determined by SDS PAGE
纯化方法AC
内毒素Not analyzed
表达系统HEK293 cell
活性Not tested
标签Tag Free
缓?冲?液PBS (pH=7.4)
保存条件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.

SWISS:
Q13253

Gene ID:
9241

产品图片
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.

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