产品编号 | bs-41322P |
英文名称 | Recombinant human CH25H protein, His |
中文名称 | 重组胆固醇25羟化酶蛋白 |
别????名 | C25H; CH25H; Cholesterol 25 hydroxylase; Cholesterol 25 monooxygenase; EC 1.14.99.38; EC=1.14.99.38; h25OH; CH25H_HUMAN; Recombinant human CH25H protein, His?? |
理论分子量 | 14kDa |
检测分子量 | 14 kDa |
性????状 | Lyophilized or Liquid |
浓????度 | >0.5 mg/ml |
物????种 | Human |
序????列 | 140-272/272 |
纯????度 | >95% as determined by SDS-PAGE |
纯化方法 | AC |
内毒素 | Not analyzed |
表达系统 | E.coli |
活性 | Not tested |
标签 | His |
缓?冲?液 | 4 M Urea (pH=9.0) with 300 mM NaCl |
保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 | CH25H (Cholesterol 25-hydroxylase), also known as h25OH, is a 272 amino acid endoplasmic membrane protein that belongs to the sterol desaturase family. CH25H contains clusters of histidine residues essential for catalytic activity and is involved in cholesterol and lipid metabolism. CH25H catalyzes the formation of 25-hydroxycholesterol from cholesterol leading to the repression of cholesterol biosynthetic enzymes. CH25H regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. CH25H utilizes diiron cofactors to catalyze the hydroxylation of hydrophobic substrates.
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产品图片 | The purity of the protein is greater than 80% as determined by reducing SDS-PAGE. |
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