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首页 > 抗体蛋白 > 抗体
Purified anti-MMP2 Antibody
产品名称：
Purified anti-MMP2 Antibody
产品类别：
抗体
产品编号：
680002
产品应用：
680002
[价格]
规格 价格 库存
100µg ￥ 215 1

产品详情

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human MMP-2, amino acids (Ala30-Cys660) (Accession# NP_004521.1) with a C-terminal His tag and a linker sequence. It is expressed in 293E cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Swieboda D, et al. 2020. Front Immunol. 1.697916667. PubMed
RRID
AB_2566323 (BioLegend Cat. No. 680002)

Antigen Details

Structure
Monomer. Human MMP2 contains 660 amino acids with a predicted molecular weight of 73.9 kD. Upon activation by p-aminophenylmercuric acetate (APMA), it has a predicted molecular weight of 62 kD.
Distribution

MMP2 is expressed by fibroblasts, endothelial cells, alveolar epithelial cells, and macrophages.

Function
MMP2 is a metalloproteinase that specifically cleaves type IV collagen, which is the major structural component of basement membranes. MMP2 is thought to contribute to the invasion and the metastasis of various human malignancies.
Interaction
Fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans, decorin, osteopontin, and IBP-3.
Ligand/Receptor
TIMPs, CLL7, and thrombospondin 1.
Cell Type
Endothelial cells, Epithelial cells, Fibroblasts, Macrophages
Biology Area
Angiogenesis, Cell Adhesion, Cell Biology, Neuroinflammation, Neuroscience
Molecular Family
Enzymes and Regulators
Antigen References

1. Nagase H and Woessner JF. 1999. J. Biol. Chem. 274:21491.
2. Martignetti JA, et al. 2001. Nat. Genet. 28:261.
3. Itoh T, et al. 1997. J. Biol. Chem. 272:22389.
4. Passlick B, et al. 2000. Clin. Cancer Res. 6:3944.
5. Qian Q, et al. 2010. Cancer Invest. 28:661.
6. Hoikkala S, et al. 2006. Cancer Lett. 236:125.
7. Yamamura T, et al. 2002. Cancer 35:249.

Gene ID
4313 View all products for this Gene ID
UniProt
View information about MMP-2 on UniProt.org

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