Purified anti-Granzyme B Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 300	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant human Granzyme B produced in the 293E cell line.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0?- 10??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Spolski R et al. 2019. Elife. 8 pii: e45501. PubMed

RRID

AB_2565266 (BioLegend Cat. No. 674602)

Antigen Details

Structure: 247 amino acids with a molecular weight of approximately 28 kD
Distribution: Cytotoxic T cells, NK cells, and neutrophils.
Function: Granzyme B is able to induce target cell apoptosis by activating caspase independent pathways. Granzyme B is induced in CD8⁺ T lymphocytes with ConA / IL-2 and CD4⁺ T lymphocytes with anti-CD3/CD28 or anti-CD3/CD46.
Interaction: Targets of CTL and NK cells.
Cell Type: B cells, Dendritic cells, Neutrophils, NK cells, T cells
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Innate Immunity, Neuroscience, Signal Transduction
Molecular Family: Enzymes and Regulators, Proteases
Antigen References: 1. Edwards KM, et al. 1999. J. Biol. Chem. 274:30468.
2. Grossman WJ, et al. 2004. Blood 104:2840.
3. Heusel JW, et al. 1994. Cell 76:977.
4. Schmid J and Weissmann C. 1987. J. Immunol. 139:250.
5. Trapani JA, et al. 1988. Proc. Natl. Acad. Sci. USA 85:6924.
6. Hiebert PR and Granville DJ. 2012. Trends Mol. Med. 18:732.
7. Saito Y, et al. 2011. J. Cardiol. 57:141.
8. Ewen CL, et al. 2012. Cell Death Differ. 1:28.
Gene ID: 3002 View all products for this Gene ID
UniProt: View information about Granzyme B on UniProt.org

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