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Purified anti-human PCSK9 Antibody
产品名称：
Purified anti-human PCSK9 Antibody
产品类别：
抗体
产品编号：
537502
产品应用：
537502
[价格]
规格 价格 库存
500µg ￥ 581 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA Capture - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 1.0 - 4.0 ?g/mL is recommended. To obtain a linear standard curve, serial dilutions of PCSK9 recombinant protein ranging from 58.6 to 3750 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The purified M1118E3 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated Poly5250 antibody (Cat. No. 525004) as the detection antibody and Recombinant Human PCSK9 (ELISA Std.) (Cat. No. 592509)

RRID
AB_2783350 (BioLegend Cat. No. 537502)

Antigen Details

Structure
Monomer
Distribution

Hepatocytes, neuro-epithelioma, colon carcinoma, Schwann cells

Function
PCSK9 regulates LDLR, VLDLR, APOER, and APOER2 levels, and, therefore LDLc level. PCSK9 is regulated by SREBP-2
Interaction
Hepatocytes
Ligand/Receptor
LDLR, VLDLR, APOB, LRP1, LRP8
Biology Area
Cell Biology, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
Enzymes and Regulators
Antigen References
  1. Seidah NG, et al. 2003. Proc Natl Acad Sci USA. 100:928.
  2. Naureckiene S, et al. 2003. Arch Biochem Biophys. 420:55.
  3. Costet P, et al. 2008. Trends Biochem Sci. 33:426.
  4. Tibolla G, et al. 2011. Nutr Metab Cardiovasc. Dis. 21:835.
Gene ID
255738 View all products for this Gene ID
UniProt
View information about PCSK9 on UniProt.org

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