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首页 > 抗体蛋白 > 抗体
Purified anti-PCSK9 Antibody
产品名称：
Purified anti-PCSK9 Antibody
产品类别：
抗体
产品编号：
677502
产品应用：
677502
[价格]
规格 价格 库存
100µg ￥ 265 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse PCSK9, amino acids Gln35-Gln694, expressed with a C-terminal His tag and a linker sequence in 293E cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Sun H, et al. 2018. J Lipid Res. 59:207. PubMed
RRID
AB_2565908 (BioLegend Cat. No. 677502)

Antigen Details

Structure
Monomer. The molecular mass of a full-length and mature protein is 74.8 kD and 53.7 kD, respectively.
Distribution
Hepatocytes, renal cells, neuroepithelioma, and Schwann cells.
Function
PCSK9 regulates LDLR, VLDLR, APOER, and APOER2 levels, and therefore, LDLc levels. PCSK9 is regulated by SREBP-2.
Interaction
Hepatocytes.
Ligand/Receptor
LDLR, VLDLR, APOB, LRP1, and LRP8.
Biology Area
Cell Biology, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
Enzymes and Regulators
Antigen References

1. Seidah NG, et al. 2003. Proc. Natl. Acad. Sci. USA 100:928.
2. Naureckiene S, et al. 2003. Arch. Biochem. Biophys. 420:55.
3. Costet P, et al. 2008. Trends Biochem. Sci. 33:426.
4. Grefhorst A, et. al. 2008. J. Lipid Res. 49:1303.
5. Tavori H, et al. 2013. Circulation 127:2403.
6. Denis M, et al. 2012. Circulation 125:894.
7. Tibolla G, et al. 2011. Nutr. Metab. Cardiovasc. Dis. 21:835.

Gene ID
100102 View all products for this Gene ID
UniProt
View information about PCSK9 on UniProt.org

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