Purified anti-EPO Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 288	1

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse EPO
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This product does not cross react with human EPO.
RRID: AB_2563470 (BioLegend Cat. No. 660302)

Structure: 166 amino acid, predicted molecular weight of approximately 18.6 kD, migrates at approximately 30-34 kD as a result of its glycosylation.
Distribution: EPO is primarily expressed in the kidneys (70-90% of the total EPO) and liver. EPO is expressed by hepatocytes, cortical interstitial fibroblasts in ischemic kidneys, astrocytes, and neurons under hypoxia.
Function: EPO is the major regulator of differentiation, proliferation, and survival of erythroid progenitors. EPO expression is induced by hypoxia, HIF, and other transcription factors. EPO has a possible role in neuroprotection.
Interaction: Erythroid progenitor cells.
Ligand/Receptor: EpoR (homodimer).
Cell Type: Fibroblasts, Neurons
Biology Area: Cell Biology
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Shoemaker CB, et al. 1986. Mol. Cell. Biol. 6:849.
2. McDonald JD, et al. 1986. Mol. Cell. Biol. 6:842.
3. Chin K, et al. 2000. Brain Res. Mol. Brain Res. 81:29.
4. Snow JW, et al. 2009. J. Biol. Chem. 284:29310.
5. Kassouf MT, et al. 2010. Genome Res. 2010:20:1064.
6. Paliege A, et al. 2010. Kidney Int. 77:312.
7. Sinclair AM, et al. 2010. Blood 115:4264.
8.?Alnaeeli M, et al. 2012. Anat. Res. Int. 2012:953264.
Gene ID: 2056 View all products for this Gene ID
UniProt: View information about EPO on UniProt.org