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Brilliant Violet 421™ anti-mouse CD184 (CXCR
产品名称：
Brilliant Violet 421™ anti-mouse CD184 (CXCR
产品类别：
抗体
产品编号：
146511
产品应用：
146511
[价格]
规格 价格 库存
50µg ￥ 270 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CXCR4-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: in vivo blocking1

Application References

(PubMed link indicates BioLegend citation)
  1. Costa MJ, et al. 2018. PLoS One. 13:e0194688 (Block) PubMed
Product Citations
  1. Brulois K, et al. 2020. Nat Commun. 3.095833333. PubMed
  2. Girousse A et al. 2019. Cell Rep. 27(2):323-333 . PubMed
  3. Biram A, et al. 2020. Cell Rep. 30:1910. PubMed
  4. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  5. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  6. Luo W et al. 2018. Immunity. 48(2):313-326 . PubMed
  7. Kulkarni U, et al. 2019. Mucosal Immunol. 12:545. PubMed
  8. Beidaq A, et al. 2016. J Immunol. 197: 1567 - 1576. PubMed
  9. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  10. Miyauchi K, et al. 2021. Nat Commun. 12:3789. PubMed
  11. Subramaniam N, et al. 2021. Blood Adv. 5:1259. PubMed
  12. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  13. Chen KE, et al. 2021. J Neuroinflammation. 18:140. PubMed
RRID
AB_2562788 (BioLegend Cat. No. 146511)

Antigen Details

Structure
G-protein-coupled seven transmembrane receptor, 39.7 kD
Distribution

T lymphocytes, monocytes, macrophages, tissue-committed stem/progenitor cells (TCSCs), mast cells, vascular smooth muscle cells (VSMCs)

Function
Development of cardiovascular and central nervous system, hematopoiesis, and colonization of BM by fetal liver-derived hematopoietic stem cells (HSCs) during embryogenesis, homing and egress of CD34+ CXCR4+ progenitor cells from bone marrow, and their migration into peripheral tissues. Critical role in homing of cancer cells to specific metastatic sites. Possible role in the ubiquitin proteosome system.
Interaction
Robo -1
Ligand/Receptor
CXCL12 (SDF-1)
Cell Type
Macrophages, Mast cells, Mesenchymal Stem Cells, Monocytes, Neural Stem Cells, T cells
Biology Area
Angiogenesis, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Ubiquitin/Protein Degradation
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Kucia M, et al. 2005. Stem Cells 23:879.
2. Muller A, et al. 2001. Nature 410:50.
3. Saini V, et al. 2010. J. Biol. Chem. 285:15566.
4. Prasad A, et al. 2007. J. Leuko. Biol. 82:465.?
5. De Klerck B, et al. 2005. Arthritis Res. Ther. 7:R1208.
6. Rueda P, et al. 2008. PLoS One 3:e2543.?
7. Feng Y, et al. 1996. Science 272:872.

Gene ID
12767 View all products for this Gene ID
UniProt
View information about CD184 on UniProt.org

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