Purified anti-mouse CD124 (IL-4Rα) Antibody
- 产品名称：
- Purified anti-mouse CD124 (IL-4Rα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 144801
- 产品应用：
- 144801
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant Mouse IL4Rα encoding the extracellular domain (amino acid residues 26 - 233) was fused to the carboxy-terminal Fc region of human IgG1 via a linker peptide.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
- Gubin MM, et al. 2018. Cell. 175:1014. PubMed
- Maier B, et al. 2020. Nature. 580:257. PubMed
- RRID
- AB_2561554 (BioLegend Cat. No. 144801) AB_2561555 (BioLegend Cat. No. 144802)
- Structure
- 140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit
- Distribution
-
B cells, T cells, monocytes, and low levels on granulocytes.
- Function
- Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells
- Interaction
- STAT6
- Ligand/Receptor
- IL-4, IL-13
- Cell Type
- B cells, Granulocytes, Monocytes, T cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Kashiwada M, et al. 2001. J. Immunol. 167:6382.
2. Gilmour J, et al. 2008. J. Immunol. 124:437.
3. Hage T, et al. 1999. Cell 97:271.
- Gene ID
- 16190 View all products for this Gene ID
- UniProt
- View information about CD124 on UniProt.org
