Purified anti-human IL-1β Antibody
- 产品名称：
- Purified anti-human IL-1β Antibody
- 产品类别：
- 抗体
- 产品编号：
- 511601
- 产品应用：
- 511601
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ELISA Capture - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. Purified H1b-27 is useful as the capture antibody in a sandwich ELISA when used in conjunction with the biotinylated Poly5174 (Cat. No. 517403) or H1b-98 antibody (Cat. No. 511703). For ELISA capture applications, a concentration range of 2-6 ?g/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- Huang C, et al. 2019. Cell Rep. 29:4525. PubMed
- Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed
- Croden J, et al. 2021. PLoS One. 16:e0258208. PubMed
- Bando H, et al. 2019. Front Cell Infect Microbiol. 9:140. PubMed
- Watkins H, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.010. PubMed
- Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
- Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
- RRID
- AB_1236517 (BioLegend Cat. No. 511601) AB_1236518 (BioLegend Cat. No. 511602)
- Structure
- Cytokine; 17.3 kD
- Bioactivity
- Stimulates T cells, B cells, proliferation/activation of NK cells, fibroblasts, thymocytes, glioblastoma cells, astroglia, microglia
- Cell Sources
- Monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglia, glioma, keratinocytes,
- Cell Targets
- B cells, T cells, monocytes
- Receptors
- Type I IL-1R (CDw121a), Type II IL-1R (CDw121b)
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Bomford R, et al. Eds. 1989. Interleukin-1 inflammation and disease. Elsevier New York.
3. Brazel D, et al. 1991. Biotechnol. Ther. 2:241.
4. Dinarello C. 1996. Blood 87:2095.
- Regulation
- Upregulated by TNF-α, IFN-α, IFN-β, IFN-γ, bacterial endotoxins, viruses, mitogens, antigens; downregulated by IL-6, lipoproteins, lipids, and α2-macroglobulin
- Gene ID
- 3553 View all products for this Gene ID
- UniProt
- View information about IL-1beta on UniProt.org
