Alexa Fluor® 647 anti-human CD197 (CCR7) Antib
- 产品名称：
- Alexa Fluor® 647 anti-human CD197 (CCR7) Antib
- 产品类别：
- 抗体
- 产品编号：
- 353217
- 产品应用：
- 353217
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CCR7-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Red Laser (633 nm)
- Product Citations
-
- Kim MY, et al. 2021. JCI Insight. 6:. PubMed
- Preglej T, et al. 2020. JCI Insight. 5(4):. PubMed
- Causi E, et al. 2015. PLoS One. 10: 0136717. PubMed
- Zhang W, et al. 2021. Sci Adv. 7: . PubMed
- Kerstein A, et al. 2016. J Autoimmun. S0896-8411(16)30186-X. PubMed
- Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed
- Ecker C, et al. 2018. Cell Rep. 23:741. PubMed
- Medvec AR, et al. 2018. Mol Ther Methods Clin Dev. 8:65. PubMed
- Thommen D, et al. 2015. Cancer Immunol Res. 3: 1344 - 1355. PubMed
- Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
- Vikkurthi R, et al. 2022. Nat Microbiol. 7:974. PubMed
- Rakshit S, et al. 2020. Cell Rep. 33:108451. PubMed
- Hunter S, et al. 2018. J Hepatol. 69:654. PubMed
- Qin XH, et al. 2019. Langmuir. 35:1882. PubMed
- Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
- Tanner MR et al. 2017. Clinical immunology (Orlando, Fla. 180:45-57 . PubMed
- Shan L, et al. 2017. Immunity. 47:766. PubMed
- RRID
- AB_10913812 (BioLegend Cat. No. 353217) AB_10917385 (BioLegend Cat. No. 353218)
- Structure
- Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor.
- Distribution
-
T cells, B cells, NK, dendritic cells.
- Function
- The chemokine receptor CCR7 plays a pivotal role in the homing of na?ve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels.
- Ligand/Receptor
- CCL19 and CCL21.
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Yanagihara S,?et al.?1998.?J. Immunol.?161:3096.
2. Charo IF,?et al.?2006.?N. Engl. J. Med.?354:610.
3. Reif K,?et al.?2002.?Nature?416:94.
4. Nakata B,?et al.?2008.?Oncology?74:69.
5.?Brodie T.?et al. 2013.?Cytometry A.?6: 530-2.?PubMed
6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9?PubMed
7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8?PubMed
- Gene ID
- 1236 View all products for this Gene ID
- UniProt
- View information about CD197 on UniProt.org
