Alexa Fluor® 488 anti-human CD197 (CCR7) Antib
- 产品名称：
- Alexa Fluor® 488 anti-human CD197 (CCR7) Antib
- 产品类别：
- 抗体
- 产品编号：
- 353205
- 产品应用：
- 353205
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CCR7-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Blue Laser (488 nm)
- Product Citations
-
- Lagou V et al. 2018. Cell reports. 25(3):798-810 . PubMed
- Braun J, et al. 2020. Nature. 587:270. PubMed
- Mastelic-Gavillet B, et al. 2019. J Immunother Cancer. 7:257. PubMed
- Weisberg SP, et al. 2020. Cell Reports. 29(12):3916-3932.e5.. PubMed
- Sung BY, et al. 2022. J Clin Invest. 132:. PubMed
- Naaber P, et al. 2022. Cell Rep Med. 3:100716. PubMed
- Lerrer S, et al. 2021. iScience. 24:103020. PubMed
- Balan I, et al. 2022. Front Immunol. 13:940095. PubMed
- Woodruff M, et al. 2020. medRxiv. . PubMed
- Jürchott K, et al. 2016. PLoS One. 11: 0150812. PubMed
- Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
- Poon MML, et al. 2021. Cell Rep. 37:110071. PubMed
- Serrano I, et al. 2022. Front Immunol. 13:883743. PubMed
- Ickrath P, et al. 2019. Biomed Rep. 10:119. PubMed
- Ferreira-Gomes M, et al. 2021. Nat Commun. 12:1961. PubMed
- Ickrath P, et al. 2018. Int J Mol Med. 42:1116. PubMed
- RRID
- AB_10918624 (BioLegend Cat. No. 353205) AB_10916389 (BioLegend Cat. No. 353206)
- Structure
- Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor.
- Distribution
-
T cells, B cells, NK, dendritic cells.
- Function
- The chemokine receptor CCR7 plays a pivotal role in the homing of na?ve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels.
- Ligand/Receptor
- CCL19 and CCL21.
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Yanagihara S,?et al.?1998.?J. Immunol.?161:3096.
2. Charo IF,?et al.?2006.?N. Engl. J. Med.?354:610.
3. Reif K,?et al.?2002.?Nature?416:94.
4. Nakata B,?et al.?2008.?Oncology?74:69.
5.?Brodie T.?et al. 2013.?Cytometry A.?6: 530-2.?PubMed
6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9?PubMed
7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8?PubMed
- Gene ID
- 1236 View all products for this Gene ID
- UniProt
- View information about CD197 on UniProt.org
