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Brilliant Violet 421™ anti-human CD183 (CXCR
产品名称：
Brilliant Violet 421™ anti-human CD183 (CXCR
产品类别：
抗体
产品编号：
353715
产品应用：
353715
[价格]
规格 价格 库存
25tests ￥ 204 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CXCR3 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Product Citations
  1. Apostolidis SA, et al. 2021. Nat Med. 27:1990. PubMed
  2. Cuadrado E, et al. 2018. Immunity. 48:1046. PubMed
  3. Bouwer A, et al. 2014. J Immunol. 192:2514. PubMed
  4. Ma C, et al. 2015. J Allergy Clin Immunol. . PubMed
  5. Ahmed R, et al. 2020. Cell Rep. 33:108501. PubMed
  6. Tardif V, et al. 2019. Nat Commun. 10:823. PubMed
  7. Lam AJ, et al. 2021. Cell Reports. 36(5):109494. PubMed
  8. Obradovic A, et al. 2021. Cell. 184(11):2988-3005.e16. PubMed
  9. Painter MM, et al. 2021. Immunity. 54:2133. PubMed
  10. Cottineau J, et al. 2017. J Clin Invest. 127:1991. PubMed
  11. Qu K et al. 2017. Cancer cell. 32(1):27-41 . PubMed
  12. NULL, et al. 2022. Cell. 185:916. PubMed
  13. Lundell A, et al. 2017. Sci Rep. 7:39904. PubMed
  14. Lederer K, et al. 2022. Cell. . PubMed
  15. Pandya J, et al. 2016. J Leukoc Biol. 100: 823 - 833. PubMed
  16. Adel–Patient K, et al. 2018. Clin Transl Allergy. 8:38. PubMed
  17. Yost KE, et al. 2019. Nat Med. 25:1251. PubMed
RRID
AB_11124720 (BioLegend Cat. No. 353715) AB_2561448 (BioLegend Cat. No. 353716)

Antigen Details

Structure
CXC-chemokine receptor, G protein-coupled receptor, seven-pass transmembrane receptor
Distribution

T cell subset, NK cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors, mast cells, alveolar macrophages, eosinophils, and airway epithelial cells

Function
Essential in T cell recruitment to sites of inflammation
Ligand/Receptor
CXCL9, CXCL10, and CXCL11
Cell Type
Dendritic cells, Eosinophils, Epithelial cells, Hematopoietic stem and progenitors, Macrophages, Mast cells, NK cells, T cells, Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Loetscher M, et al. 1996. J. Exp. Med. 184:963.
2. Cole KE, et al. 1998. J. Exp. Med. 187:2009.
3. Aksoy MO, et al. 2006. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L909.
4. Curbishley SM, et al. 2005. Am. J. Pathol. 167:887.
5. Turner JE, et al. 2007. Mini. Rev. Med. Chem. 7:1089.
6. Wenzel J, et al. 2008. J. Invest. Dermatol. 128:67.

Gene ID
2833 View all products for this Gene ID
UniProt
View information about CD183 on UniProt.org

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