Alexa Fluor® 700 anti-mouse CD206 (MMR) Antibo
- 产品名称：
- Alexa Fluor® 700 anti-mouse CD206 (MMR) Antibo
- 产品类别：
- 抗体
- 产品编号：
- 141733
- 产品应用：
- 141733
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD206 (MMR)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 700 under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
FC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor? 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Red Laser (633 nm)
- Application Notes
Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.
- Application References
(PubMed link indicates BioLegend citation) -
- Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
- Ito H, et al. 2012. J Am Soc Nephrol. 23:1797. PubMed
- Yang X, et al. 2015. PNAS. 112:2900. PubMed
- Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
- Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
- Product Citations
-
- Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
- Garcia-Fabiani MB, et al. 2020. Methods Enzymol. 632:369. PubMed
- Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
- Rao E, et al. 2021. Sci Immunol. 6:. PubMed
- Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
- Wu X, et al. 2021. Elife. 10:. PubMed
- Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
- Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
- Shi R, et al. 2022. Theranostics. 12:875. PubMed
- Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
- Utz SG, et al. 2020. Cell. 181(3):557-573. PubMed
- Tian L, et al. 2022. Clin Cancer Res. 28:201. PubMed
- Barnette DN, et al. 2018. JCI Insight. 3. PubMed
- Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
- Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
- RRID
- AB_2629636 (BioLegend Cat. No. 141733) AB_2629637 (BioLegend Cat. No. 141734)
- Structure
- Type I transmembrane protein, 175 kD, C-type lectin superfamily
- Distribution
-
Macrophages, dendritic cells, Langerhans cells, liver endothelial cells
- Function
- Pathogen recognition, endocytosis and phagocytosis, antigen presentation
- Ligand/Receptor
- Antigen containing mannose, fucose, or an N-acetyl glucosamine
- Cell Type
- Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
-
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.
- Gene ID
- 17533 View all products for this Gene ID
- UniProt
- View information about CD206 on UniProt.org
