Alexa Fluor® 488 anti-mouse CD206 (MMR) Antibo
- 产品名称：
- Alexa Fluor® 488 anti-mouse CD206 (MMR) Antibo
- 产品类别：
- 抗体
- 产品编号：
- 141709
- 产品应用：
- 141709
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD206 (MMR)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
FC, IHC-F?- Verified
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?L?volume. For immunohistochemistry on frozen tissue sections, a concentration range of 2.5 - 5.0 ?g/mL?is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Blue Laser (488 nm)
- Application Notes
Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.
- Application References
(PubMed link indicates BioLegend citation) -
- Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
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- Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
- Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
- Product Citations
-
- Divakaruni AS et al. 2018. Cell metabolism. 28(3):490-503 . PubMed
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- Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
- Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
- Xu DQ, et al. 2021. Acta Pharmacol Sin. 42:1080. PubMed
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- Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
- AR P, et al. 2016. Circ Res. 118: 400-409. PubMed
- Palathingal Bava E, et al. 2022. JCI Insight. 7:. PubMed
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- Ahmad F, et al. 2021. J Am Heart Assoc. 10:e017524. PubMed
- Tu W, et al. 2021. Cell Death Dis. 12:882. PubMed
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- Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
- Alhudaithi SS, et al. 2020. Mol Pharm. 17:4691. PubMed
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- Molgora M, et al. 2020. Cell. 182:886. PubMed
- Zhang F, et al. 2021. J Immunol Res. 2021:5521051. PubMed
- Tang PC, et al. 2022. Adv Sci (Weinh). 9:e2101235. PubMed
- Mu?oz M, et al. 2022. ACS Nano. . PubMed
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- Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
- RRID
- AB_10933252 (BioLegend Cat. No. 141709) AB_10900445 (BioLegend Cat. No. 141710)
- Structure
- Type I transmembrane protein, 175 kD, C-type lectin superfamily
- Distribution
-
Macrophages, dendritic cells, Langerhans cells, liver endothelial cells
- Function
- Pathogen recognition, endocytosis and phagocytosis, antigen presentation
- Ligand/Receptor
- Antigen containing mannose, fucose, or an N-acetyl glucosamine
- Cell Type
- Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
-
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.
- Gene ID
- 17533 View all products for this Gene ID
- UniProt
- View information about CD206 on UniProt.org
