Purified anti-human ACE2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 124	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Recombinant protein cover extracellular domain of ACE2 (Gln 18-Ser740)

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

IHC-P - Quality tested
WB - Verified

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 ?g/mL is suggested. For western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Mamedov T, et al. 2021. Front Plant Sci. 12:742875. PubMed
Schwabenland M, et al. 2021. Immunity. . PubMed
Song J, et al. 2022. PLoS Biol. 20:e3001805. PubMed

RRID

AB_2860958 (BioLegend Cat. No. 375801) AB_2860959 (BioLegend Cat. No. 375802)

Antigen Details

Structure

Type one transmemberance protein. Protein sequence consistent extracellular domain (Gln 18-Ser740 ) contain cytalitic domain, transmembrane domain (AA741-AA761) and cytoplasmic domain (AA762-AA805).

Distribution

Type II alveolar cells (AT2) of lung, esophagus upper and stratified epithelial cells, kidney proximal tubule cells,? enterocytes in ileum and colon, cholangiocyte in bile duct, myocardial cells in heart, endothelium and vascular smooth muscle cells

Function

Catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction

Interaction

Angiotensin II, ADAM17, TMPRSS2

Ligand/Receptor

Functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus)

Cell Type

Monocytes

Biology Area

Angiogenesis, COVID-19, Immunology

Molecular Family

Enzymes and Regulators

Antigen References