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Purified anti-CREB1 Antibody
产品名称:
Purified anti-CREB1 Antibody
产品类别:
抗体
产品编号:
948301
产品应用:
948301
[价格]
规格 价格 库存
25µg ¥ 118 1

产品详情

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Partial recombinant human CREB1 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0?- 5.0??g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone recognizes endogenous CREB1 proteins at 43 kD in both human and mouse cell lysates.

RRID
AB_2894537 (BioLegend Cat. No. 948301) AB_2894537 (BioLegend Cat. No. 948302)

Antigen Details

Structure
CREB1 contains 327 amino acids at a predicted molecular weight at 35 kD.
Distribution

Ubiquitously expressed /Nucleus

Function
Under physiological conditions, CREB1 protein maintain cellular survival, proliferation, anti-inflammatory immune responses and modulates the development of the nervous system by serving as a neuroprotective role. Under pathological conditions, increased level of CREB1 associates with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin’s lymphoma, chronic lymphatic leukemia (CLL), melanoma, hepatocellular, renal cell, ovarian, prostate, lung, gastric, esophageal, pancreatic, and breast tumors. CREB1 is also involved in the aging process by regulating the downstream signals of mitochondria dysfunction.
Interaction
CREB1 interacts with CREBBP, CRTC2, EP300, CRTC1, JUN, AKT1, CAMK4, FOS, RPS6KA1, RPS6KA3, CaMKII, CaMKIV, PKA, PKC, MSK, RSK, AKT, and MK2.
Cell Type
B cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, NK cells, T cells
Biology Area
Cell Biology, Transcription Factors
Antigen References
  1. Andre S, et al. 2020. Cell Mol Life Sci. 77:4049-4067
  2. Pei-Hsuan L, et al. 2020. Diagnostics. 10:295
  3. Kensuke S, et al. 2011. J Neurochem. 116:1-9
  4. Andy YW, et al. 2010. J Immunol. 185:6413-6419
  5. TA, et al. 2002. EMBO J. 21:53-63?
Gene ID
1385 View all products for this Gene ID
UniProt
View information about CREB1 on UniProt.org

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