Ultra-LEAF™ Purified anti-human CCL22 Antibo-上海雅吉生物科技有限公司

规格	价格	库存
1mg	￥ 715	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human CCL22
Formulation: 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
Preparation: The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration: The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
Application: Neut - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by neutralizing activity. The ND₅₀ is 1.5 - 4.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2650729 (BioLegend Cat. No. 694403) AB_2650730 (BioLegend Cat. No. 694404)

Structure: Chemokine
Distribution: Macrophages, NK cells, IFNγ stimulated human keratinocytes, thymic epithelial cells and intestinal epithelial cells.
Function: Induces the migration of CCR4⁺ Th2 cells, Tregs, DC, and NK cells. Induced by LPS and CD40 antibody in macrophages. Upregulated by Th2 cytokines (IL-4 and IL-5) and downregulated by Th1 cytokines (IFNγ).
Interaction: Dendritic cells, NK cells, Th2 cells, T regs, CLA⁺ skin-homing memory/effector T cells.
Ligand/Receptor: CCR4
Cell Type: Epithelial cells, Macrophages, NK cells
Biology Area: Cell Biology, Immunology
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Godiska R, et al. 1997. J. Exp. Med. 185:1595.
2. Imai T, et al. 1998. J. Biol. Chem. 273(3):1764-8.
3.?Yamashita U and Kuroda E. 2002. Crit. Rev. Immunol. 22:105.
4.?Horikawa T, et al. 2002. Int. Immunol. 14:767.
5.?Mailloux AW, et al. 2009. J. Immunol. 182:2753.
6. Dogan RN, et al. 2011. J. Leukoc. Biol. 89:93.
7. Osborn O, et al. 2011. Cytokine 53:311.?
Gene ID: 6367 View all products for this Gene ID
UniProt: View information about CCL22 on UniProt.org