Purified anti-α-Synuclein, aggregated Antibo-上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 89	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Aggregated recombinant human alpha-synuclein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

IHC-P - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5?- 5.0??g/mL?for chromogenic staining and 0.1?- 2.0??g/mL?for fluorescent staining is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Kumar ST, et al. 2020. Neurobiol Dis. 146:105086. PubMed

RRID

AB_2810765 (BioLegend Cat. No. 865001) AB_2810766 (BioLegend Cat. No. 865002)

Antigen Details

Structure

Human α-synuclein is a 140 amino acid protein with a molecular mass of 14 kD.

Distribution

Tissue distribution: Primarily nervous system, but lower expression in other tissues such as blood and skin.
Cellular distribution: Cytoskeleton, cytosol, lysosome, mitochondria, nucleus, plasma membrane, and extracellular.

Function

α-synuclein plays several roles in synaptic activity such as synaptic vesicle trafficking and neurotransmitter release. It is also involved in the regulation of gene expression.

Interaction

Interacts with various proteins, such as UCHL1, phospholipase D, histones and SNARE components.

Cell Type

Neurons

Biology Area

Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Synaptic Biology

Molecular Family

α-Synuclein, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis

Antigen References