Purified anti-Apo E, 154-162 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 112	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: KLH conjugated Apo E peptide encompassing amino acids 154-162.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Direct ELISA, IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 ?g per mL.?For Direct ELISA applications, a concentration range of 0.004 - 0.4 ?g/mL is recommended.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 5.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody cross-reacts with Apo E₂, Apo E₃, and Apo E₄.
RRID: AB_2728599 (BioLegend Cat. No. 852801) AB_2728600 (BioLegend Cat. No. 852802)

Antigen Details

Structure

Human Apo E is a 299 amino acid protein with a molecular mass of 32 kD, and exists as 3 major alleles, Apo E₂, Apo E₃, and Apo E₄.

Distribution

Tissue sources: Ubiquitously expressed. Highest levels in liver, brain, spleen, adrenal gland, and kidney.
Cellular distribution: Plasma membrane, nucleus, endoplasmic reticulum, golgi apparatus, endosome, and extracellular.

Function

Apo E is involved in lipoprotein metabolism as well as the transport of fat-soluble vitamins, and cholesterol. Apo E also forms complexes with amyloid beta peptides leading to its uptake and degradation by microglia.

Interaction

Tau, amyloid beta

Ligand/Receptor

LDL receptor, SORL1.

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Apolipoproteins

Antigen References