Purified anti-Lck Phospho (Tyr505) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 112	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human Lck peptide phosphorylated at Tyr 505.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 2.0 ?g per ml (1:250-1:5000 dilution). It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This clone is predicted to recognize both 58 and 61 kDa isoforms based off the presence of the immunizing epitope in both proteins. This clone may also recognize certain phosphorylated SRC tyrosine kinase family members due to high sequence similarity.
RRID: AB_2716046 (BioLegend Cat. No. 684301) AB_2716047 (BioLegend Cat. No. 684302)

Structure: 509 and 539 amino acid isoforms with predicted molecular weights of 58 and 61 kD, respectively. Contains N-terminal domain with myristylation and palmitoylation sites, a kinase domain, and SH2 and SH3 domains that mediate protein-protein interactions bet
Distribution: T cells
Function: T cell receptor signaling
Interaction: AXL, CD2, CD4, CD5, CD8, CD44, CD45, CD122, PI4K, VAV1, RASA1, FYB, CDK1, RAF1, ZAP70, SYK, RUNX3
Cell Type: T cells
Biology Area: Cell Biology, Signal Transduction
Molecular Family: Phospho-Proteins, Protein Kinases/Phosphatase
Antigen References: 1.?Philipsen L, et al. 2017. Sci Signal. eaaf4736?
2. Moogk D, et al. 2016. J. Immunol. 197:644.
3. Klammt C, et al. 2015. Nat. Immunol. 16:961.
4. Cancer Genome Atlas Network. 2015. Cell. 161:1681.
5. Casas J, et al. 2014. Nat. Commun. 5:5624.
6. McNeill L, et al. 2007. Immunnity. 27:425.
7. Lefebvre DC, et al. 2003. Biochem. Biophys. Acta. 1650:40.
8. Kabouridis PS. 2003. Biochem J. 371:907.?
Gene ID: 3932 View all products for this Gene ID
UniProt: View information about Lck Phospho Tyr505 on UniProt.org