HRP anti-Tau, 368-441 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 147	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant C-terminal fragment of human 4R Tau protein encompassing amino acid residues 231-441.
Formulation: This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Preparation: The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Application: WB - Quality tested
IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 ?g per ml. For immunohistochemistry, a concentration range of 2.0 - 5.0 ?g/ml is suggested.?It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody cross-reacts with human 3R and 4R Tau isoforms, and recognizes endogenous human Tau in brain lysates by WB. The antibody has minimal reactivity with mouse Tau protein.
RRID: AB_2734636 (BioLegend Cat. No. 851203) AB_2734637 (BioLegend Cat. No. 851204)

Antigen Details

Structure

Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.

Distribution

Tissue distribution: central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: cytoskeleton, nucleus, plasma membrane, and cytosol.

Function

Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Interaction

Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, Alpha-synuclein

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Tau

Antigen References