Purified anti-Tau, 359-373 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 112	1

Product Details

Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant fragment of human 4R Tau protein (K18) encompassing the microtubule binding domains.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
IHC-P, Direct ELISA - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g/ml.?For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.2 - 1.0 ?g/ml is suggested. For Direct ELISA, a concentration range of 0.01 - 1.0 ?g/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody cross-reacts with 3R and 4R human Tau isoforms, and recognizes endogenous human, mouse, and rat Tau in brain lysates by WB.?
RRID: AB_2721760 (BioLegend Cat. No. 851401) AB_2721761 (BioLegend Cat. No. 851402)

Antigen Details

Structure

Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.

Distribution

Tissue distribution: central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: cytoskeleton, nucleus, plasma membrane, and cytosol.

Function

Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Interaction

Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, Alpha-synuclein

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Tau

Antigen References