Ultra-LEAF™ Purified anti-human M-CSF Antibo-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 270	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant human M-CSF

Formulation

0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.

Preparation

The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Concentration

The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.

Application

Neut -?Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by neutralizing activity. The ND₅₀?is 0.01 - 0.05 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed

RRID

AB_2715880 (BioLegend Cat. No. 699203) AB_2715881 (BioLegend Cat. No. 699204)

Antigen Details

Structure: Disulfide-linked glycosylated homodimer
Distribution: M-CSF is released by fibroblasts, breast cancer cell lines, alveolar macrophages, stromal bone marrow cells, endothelial cells, and mesenchimal cells.
Function: Key regulator of the survival, proliferation, and differentiation of mononuclear phagocytes and plays a central role in the regulation of osteoclastogenesis. Regulates the development of Paneth cells, Langerhans cells, lamina propria dendritic cells, and microglia.
Interaction: Monocytes, macrophages, mononuclear phagocyte precursors, microglia, proliferating smooth muscle cells, umbilical vein endothelial cells, and breast cancer cell lines.
Ligand/Receptor: M-CSFR or CSF1R (CD115)
Biology Area: Cell Biology, Cell Proliferation and Viability, Immunology
Molecular Family: Cytokines/Chemokines, Growth Factors
Antigen References: 1. Kawasaki ES,?et al.?1985.?Science?230:291.
2. Wei S,?et al.?2010.?J. Leuko. Biol.?88:495.
3. Hodge JM,?et al.?2011.?PloS One?6:e21462.
4. Morandi A,?et al.?2011.?PloS One?6:e27450.
5. Erblich B,?et al.?2011.?PloS One?6:e26317.
6. MacDonald KP,?et al.?2010.?Blood?116:3955.
Gene ID: 1435 View all products for this Gene ID
UniProt: View information about M-CSF on UniProt.org

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