Ultra-LEAF™ Purified anti-mouse CCL20 (MIP-3-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 325	1

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant mouse CCL20 (MIP-3α)
Formulation: 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
Preparation: The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration: The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
Application: Neut - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant mouse CCL20 (MIP-3α) (Cat. No. 582306) at 0.3 ng/mL on mouse Baf3-hCCR6 transfectant chemoattractant cells. ND₅₀ range: 0.08 - 0.4 ?g /mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2894527 (BioLegend Cat. No. 942903) AB_2894527 (BioLegend Cat. No. 942904)

Antigen Details

Structure

Chemokine

Distribution

Monocytes, T cells, neutrophils, endothelial cells, fibroblasts, keratinocytes, synoviocytes, DCs, pulmonary and intestinal epithelial cells, dermal microvascular endothelial cells

Function

Chemoattracts immature dendritic cells at sites of injury, upregulated by mediators of inflammation such as TNF or LPS, induced by Th17 cytokines (IL-17A, IL-22, and TNF-α) in keratinocyte.

Interaction

T cells, Th17, Tregs, B cells, DC subsets including CD11b+ CD8α-myeloid DCs, Langerhans cells (LC), CD34+ cell-derived immature myeloid DCs, and immature monocyte-derived DCs

Ligand/Receptor

CCR6 (CD196)

Antigen References