Purified anti-ZAP-70 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 206	1

规格

价格

库存

100µg

￥ 206

Product Details

Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human ZAP 70 peptide phosphorylated at Y493. Complete Freund’s adjuvant.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: CD3, CD19, and CD56 co-staining indicates that this clone does not bind B-cells and will not bind Syk. Clone A16043B cross-reacts with mouse species.

This clone, A16043B, recognizes both non-phosphorylated ZAP-70 and phosphorylated forms of ZAP-70.
RRID: AB_2810698 (BioLegend Cat. No. 693502)

Structure: Protein tyrosine kinase, contains two SH2 domains, 70 kD.
Distribution: T cells, NK cells, and B-cell chronic lymphocytic leukemia (B-CLL).
Function: Signal transduction, associates with the T-cell antigen receptor zeta chain tyrosine-based activation motif when phosphorylated. Defects in ZAP70 causes selective T cell defect.
Ligand/Receptor: Binds to CD3 zeta chain, also associates with a variety of proteins including SLA, Fyn, RasGap, Lck, Vav1, and Shc.
Cell Type: Leukemia, NK cells, T cells
Biology Area: Cell Biology, Immunology, Signal Transduction
Molecular Family: TCRs
Antigen References: 1. Qian D, et al. 1997. J. Exp. Med. 185:1253. (ICFC)
2. Crespo M, et al. 2003. N. Engl. J. Med. 348:1764. (WB, IP)
3. Jamroziak K, et al. 2009. Cancer Epidemiol. Biomarkers Prev. 18:945.
Gene ID: 7535 View all products for this Gene ID 22637 View all products for this Gene ID
UniProt: View information about ZAP-70 on UniProt.org