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Purified anti-MRP-14 (S100A9) Antibody
产品名称:
Purified anti-MRP-14 (S100A9) Antibody
产品类别:
抗体
产品编号:
600301
产品应用:
600301
[价格]
规格 价格 库存
25µg ¥ 101 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human S100A8/S100A9 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 0.5 ?g per mL (1:1000-1:10000). It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone does not recognize S100A8. The 114 amino acid recombinant S100A9 protein has a predicted Mw of ~13 kD for monomer and ~26 kD for dimer.

Product Citations
  1. Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
RRID
AB_2721746 (BioLegend Cat. No. 600301) AB_2721747 (BioLegend Cat. No. 600302)

Antigen Details

Structure
Belongs to S100 family of proteins containing 2-EF-hand calcium -binding motifs, forms non-covalently associated complexes with another S100 family member MRP-8. S100A9 has 114 amino acids with the predicted Mw of ~13 kDa.
Distribution

MDSCs, neutrophils, monocyte, and ileal tissue eosinophils

Function
Calcium-dependent activation, immunomodulating and antiproliferative, endogenous activator of Toll-like receptor 4
Interaction
Calcium, S100A8
Ligand/Receptor
RAGE, TLR4
Cell Type
Neutrophils, Monocytes, Eosinophils
Biology Area
Cancer Biomarkers, Cell Biology, Immunology, Innate Immunity
Antigen References

1.?Loser K, et al. 2010. Nat. Med. 16:713.
2.?Cheng P, et al. 2008. J. Exp. Med. 205:2235.
3. Leukert N, et al. 2006. J. Mol. Biol. 359:961-72.
4.?Lagasse E, et al. 1988. Mol. Cell. Biol. 8:2402.
5.?Zhao F, et al. 2012. Immunology. 136:176.

Gene ID
6280 View all products for this Gene ID
UniProt
View information about MRP-14 on UniProt.org

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