Ultra-LEAF™ Purified anti-Activin A Antibody-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 215	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant human Activin A.

Formulation

0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.

Preparation

The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Concentration

The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.

Application

Neut - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by neutralizing the inhibition of proliferation induced by human recombinant Activin A (30 ng/ml) on mouse plasmacytoma cell line MPC 11. ND₅₀ range:? 0.35 – 1.05 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Chen YI, et al. 2022. Nat Commun. 13:2945. PubMed

RRID

AB_2632840 (BioLegend Cat. No. 693603) AB_2632841 (BioLegend Cat. No. 693604)

Antigen Details

Structure: Homodimer.
Distribution: BM-derived stromal fibroblasts, aortic smooth muscle cells, pulmonary epithelium, and CD4 T cells.
Function: Activin A plays a key role in embryogenesis, neointimal formation after arterial injury, early stages of chondrogenesis, osteogenesis, and hemopoiesis. Activin A drives TH9 differentiation in vitro. It is induced by Angiotensin II and alpha Thrombin and regulated by Follistatin. Activin A is induced by inflammatory cytokines and inhibited by glucocorticoids.
Interaction: The receptors for Activin A are expressed by many stromal cells, among them fibroblasts, hepatocytes, myometral cells, vascular endothelial cells, and neuronal progenitor cells.
Ligand/Receptor: Type I receptors ALK4 and ALK7, type II receptors ActRIIA and ActRIIB.
Cell Type: Fibroblasts, Epithelial cells, T cells
Biology Area: Cell Biology
Antigen References: 1. Schwall RH, et al. 1988. Mol. Endocrinol. 2:1237.
2. Hashimoto M, et al. 1992. J. Biol. Chem. 267:4999.
3. Shav-Tal Y, Zipori D. 2002. Stem Cells 20:493.
4. Dohi T, et al.?2005.?Gastroenterology?128:411.
5. Tsuchida K, et al. 2008. Endocr. J. 55:11.
6. Djouad F, et al. 2010. Stem Cell Research 1:11.
7. Sako D, et al. 2010. J. Biol. Chem. 285:21037.
8. Jones CP, et al. 2012. J.?Allergy Clin. Immunol. 129:1000.?
Gene ID: 3624 View all products for this Gene ID
UniProt: View information about Activin A on UniProt.org

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