Purified anti-Tau Phospho (Ser262) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 118	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Tau Phospho (Ser262) peptide conjugated to KLH.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P -?Quality tested
Direct ELISA -?Verified?
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested.?For Direct ELISA, the suggested use of this reagent is 0.05 - 1.0 per ml.?It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2687294 (BioLegend Cat. No. 849501) AB_2687295 (BioLegend Cat. No. 849502)

Antigen Details

Structure

Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.

Distribution

Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.

Cellular distribution: cytoskeleton, nucleus, plasma membrane, and cytosol.

Function

Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Interaction

Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, Alpha-synuclein.

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Phospho-Proteins

Antigen References

1. Augustinack JC,?et al.?2002. Acta Neuropath. 103(1):26-35.?PubMed.
2. Seubert P,?et al.?1995.?J Biol Chem?270(32):18917-22.?PubMed.
3.?Dong Y, et al. 2012.?PLoS One?7(6):e39386.?PubMed.

Gene ID