Ultra-LEAF™ Purified anti-human IGFBP-4 Anti-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 270	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human IGFBP4
Formulation: 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
Preparation: The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration: The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
Application: Blocking -?Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by blocking activity. The ND50 is 4 - 12 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2687181 (BioLegend Cat. No. 697403) AB_2687182 (BioLegend Cat. No. 697404)

Distribution: It is expressed in a variety of tissues and cells such as embryonic and postnatal brain, human osteoblast-like cells, skin fibroblasts, endothelial cells, epithelial cells, intestinal epithelium, and in a variety of tumor cells.
Function: IGFBP-4 inhibits the action of IGFI and II by preventing their binding to their receptors. The binding affinity of IGFBP-4 for IGFs is regulated by proteolysis through PAPP-A.
Ligand/Receptor: IGF-I, IGF-II
Biology Area: Angiogenesis, Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability
Antigen References: 1. Shimasaki S,?et al.?1990.?Molecular Endocrinol.?4:1451.
2.?Boldt HB,?et al.?2001.?Biochem. J.?358:359.
3.?Bunn RC and Fowlkes JL. 2003. Trends Endocrinol. Metab. 14:176.
4.?Ning Y,?et al.?2008.?Mol. Endocrinol.?22:1213.
5.?Moreno MJ,?et al.?2013.?Neoplasia.?5:554.
6.?Contois LW,?et al.?2012.?J. Biol. Chem.?287:1779.
7.?Shi Z,?et al.?2013.?Am. J. Physiol. Gastrointest. Liver Physiol.?305:G74.
Gene ID: 3487 View all products for this Gene ID
UniProt: View information about IGFBP-4 on UniProt.org