Purified anti-TICAM-2 (TRAM) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 265	1

规格

价格

库存

100µg

￥ 265

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length human TICAM-2 recombinant protein expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Daudi cells were selected as a negative control for antibody testing due to the cell line’s low expression level of the mRNA encoding TICAM2 (source: Human Protein Atlas).
RRID: AB_2563252 (BioLegend Cat. No. 659402)

Structure: 235 amino acids encode a protein with a predicted MW of 27 kD. Contains a TIR domain responsible for mediating the physical interaction with TLR4 and TICAM-1.
Distribution: Cytoplasm, golgi apparatus, endosome, cell membrane, and endoplasmic reticulum.
Function: TICAM-2 acts as a sorting adaptor molecule that transduces TLR4 signaling to TICAM-1 and regulates MYD88-independent pathway in response to LPS stimulation.
Interaction: Interacts with TRAF6, MYD88, TLR4, IL1R1, IL1RAP, IRAK2, IRAK3, TICAM1, IRF3, and IRF7.
Cell Type: Dendritic cells
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Signal Transduction
Antigen References: 1. Enokizono Y, et al. 2013. Proc. Natl. Acad. Sci. USA. 110:19908.
2. Ohnishi H, et al. 2012. PLoS One. 7:e38423.
3. Wu B, et al. 2011. Dev. Comp. Immunol. 35:764.
4. Seya T, et al. 2005. Int. J. Biochem. Cell Biol. 37:524.
5. Vogel SN, et al. 2003. Mol. Interv. 3:466.
6. Oshiumi H, et al. 2003. J. Biol. Chem. 278:49751.
Gene ID: 353376 View all products for this Gene ID
UniProt: View information about TICAM-2 on UniProt.org