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Purified anti-NLRP1 Antibody
产品名称：
Purified anti-NLRP1 Antibody
产品类别：
抗体
产品编号：
679802
产品应用：
679802
[价格]
规格 价格 库存
100µg ￥ 288 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Partial human NLRP1 recombinant protein (1-200 a.a.) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Li M, et al. 2021. Oxid Med Cell Longev. 2021:2353504. PubMed
  2. Liu L, et al. 2017. J Crohns Colitis. 10.1093/ecco-jcc/jjw219. PubMed
  3. Linder A, et al. 2020. EMBO J. 39:e105071. PubMed
RRID
AB_2566263 (BioLegend Cat. No. 679802)

Antigen Details

Structure
1473 amino acids with a predicted molecular weight of 165.8 kD. Contains an N-terminal PYD domain, a C-terminal CARD domain, a NACHT domain, and 6 leucine-rich repeats (LRR).
Distribution

Cytoplasm and nucleus.

Function
NLRP1 mediates cytochrome c-dependent apoptosis. It is a key component of the NLRP1 inflammasome, which leads to the processing and secretion of IL-1β and IL-18.
Interaction
Interacts with caspase-2, caspase-9, APAF1, EIF2AK2, and MEFV.
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
Antigen References

1. Tan CC, et al. 2015. J. Neuroinflammation 12:18.
2. Tan MS, et al. 2014. Cell Death Dis. 5:e1382.
3. Cirelli KM, et al. 2014. PLoS Pathog. 10:e1003927.
4. Maier NK, et al. 2014. J. Immunol. 192:763.
5. Levandowski CB, et al. 2013. Proc. Natl. Acad. Sci. USA 110:2952.
6. de Zoete MR, et al. 2012. Immunity 37:950.

Gene ID
22861 View all products for this Gene ID
UniProt
View information about NLRP1 on UniProt.org

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