Go-ChIP-Grade™ Purified anti-RUNX3 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 83	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human RUNX3 recombinant protein (194-304 aa).

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

ChIP -?Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by ChIP Assay. The suggested dilution for ChIP application is 1:50-1:100 by volume. It is recommended that the reagent to be titrated for optimal performance before each experiment.

Application Notes

The binding of RUNX3 antibody (9F4A17) to its target is sensitive to salt concentration.

Product Citations

Truch J, et al. 2022. Nat Commun. 13:3485. PubMed
Fang F, et al. 2022. JCI Insight. 7:. PubMed

RRID

AB_2687117 (BioLegend Cat. No. 653603) AB_2687118 (BioLegend Cat. No. 653604)

Antigen Details

Structure: 44 kD protein containing a runt domain and a proline/serine/threonine rich domain required for transcriptional activation.
Distribution: Nucleus, the tyrosine phosphorylated form is localized to the cytoplasm.
Function: RUNX3 is a transcription factor that forms a heterodimeric complex with CBF beta subunit. The RUNX3 heterodimer binds to numerous enhancers and promoters, activating or suppressing target genes. RUNX3 was reported to function as a tumor suppressor.
Interaction: RUNX3 interacts with TLE1, SUV39H1, SRC, FYN, and LCK.
Cell Type: Tregs
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Goh YM,?et al.?2010.?J. Biol. Chem.?285:10122.?
2. Vogiatzi P,?et al.?2006.?Cancer Biol. Ther.?5:371.?
3. Inoue K,?et al.?2008.?Neural Dev.?3:20.?
4. Sugai M,?et al.?2011.?J. Immunol.?186:6515.?
5. Ito K,?et al.?2005.?Cancer Res.?65:7743.?
6. Hsu PI,?et al.?2009.?Ann. Surg. Oncol.?16:1686.
Gene ID: 864 View all products for this Gene ID
UniProt: View information about RUNX3 on UniProt.org

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