Purified anti-STAT5 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 300	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human STAT5A recombinant protein (627-794 a.a.) expressed in E. coli.

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

Affinity purified.

Concentration

0.5 mg/ml

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
KO/KD-WB, ICC, IP - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 2.0 ?g per ml. For immunocytochemistry, the suggested use of this reagent is 1.0 - 5.0 ?g per ml.?For immunoprecipitation, the suggested use of this reagent is 2.0 - 10.0 μg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).

Product Citations

Zeng H, et al. 2018. Sci Adv. 4:eaar5701. PubMed

RRID

AB_2563469 (BioLegend Cat. No. 660202)

Antigen Details

Structure: 794 amino acids, predicted molecular weight of 91 kD; contains a SH2 domains responsible for homodimerization or heterodimerization.
Distribution: Cytoplasm; phosphorylated form translocates to the nucleus.
Function: STAT5 is a transcription regulator and is involved in cell differentiation, proliferation, and survival, in response to several cytokines, such as interleukins, erythropoietin, growth hormone, thrombopoietin, and prolactin.
Interaction: Forms a homodimer or a heterodimer with other family members. Interacts with NCOA1, SOCS7, CBP, p300, SMRT and ERBB4.
Cell Type: B cells, Tregs
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Signal Transduction, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Bell BD, et al. 2013. Nat. Immunol. 14:364.
2. Cholez E, et al. 2012. Leukemia. 26:2390.
3. Heltemes-Harris LM, et al. 2012. Curr. Opin. Immunol. 24:146.
4. Heltemes-Harris LM, et al. 2011. Ann. N Y Acad. Sci. 1217:18.
5. Malin S, et al. 2010. Curr. Opin. Immunol. 22:168.
6. Xu J, et al. 2009. J. Neurosci. 29:2022.
Gene ID: 6776 View all products for this Gene ID
UniProt: View information about STAT5 on UniProt.org

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