Purified anti-IRF8 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 112	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human IRF8 recombinant protein (116-220 a.a.)

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICC, IP - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 ?g per ml.?For immunocytochemistry, a concentration of 5.0 μg/ml is recommended. For immunoprecipitation, the suggested use of this reagent is 5.0 - 20 μg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Tian Y, et al. 2019. Cell Rep. 29:4482. PubMed
Schwabenland M, et al. 2021. Immunity. . PubMed
McDaniel MM, et al. 2020. Cell Reports. 31(5):107604. PubMed

RRID

AB_2562396 (BioLegend Cat. No. 656501) AB_2562395 (BioLegend Cat. No. 656502)

Antigen Details

Structure: 426 amino acids, predicted molecular weight of 48 kD, contains a IRF tryptophan pentad repeat responsible for DNA binding and a C-terminal IRF association domain (IAD) responsible for heterodimerization with other transcription factors
Distribution: Nucleus
Function: Transcription factor primarily expressed in hematopoietic cells, regulates expression of type I IFN and IFN-inducible genes in response to viral infection
Interaction: Interacts with BATF, JunB, TRIM21, and COPS2
Cell Type: B cells, Dendritic cells
Biology Area: Cell Biology, Immunology, Innate Immunity, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Minten C, et al. 2012. PLoS One. 7:e49851.
2. Xu H, et al. 2012. Nat. Immunol. 13:642.
3. Ouyang X, et al. 2011. Nat. Commun. 2:314.
4. Shin DM, et al. 2011. PLoS One. 6:e27384.
5. Wang H, et al. 2009. Immunol. Res. 43:109.
6. Qi CF, et al. 2009. Immunol. Res. 45:62.
Gene ID: 3394 View all products for this Gene ID
UniProt: View information about IRF8 on UniProt.org

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