Purified anti-TCF1 (TCF7) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 288	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial TCF1 recombinant protein (116-334 aa)

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

Affinity purified

Concentration

0.5 mg/ml

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICC, IHC-P - Verified?

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 ?g per mL. For immunocytochemmistry microscopy, a concentration range of 1-5 ?g/mL?is recommended. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1?- 10??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Sekine T, et al. 2020. Sci Immunol. 5: . PubMed
Tian Y, et al. 2019. Cell Rep. 29:4482. PubMed
Liu F, et al. 2020. J Immunother Cancer. 8:. PubMed
O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
Cobb DA, et al. 2022. J Immunother Cancer. 10:. PubMed
Bengsch B et al. 2018. Immunity. 48(5):1029-1045 . PubMed

RRID

AB_2562103 (BioLegend Cat. No. 655202)

Antigen Details

Structure: 384 amino acids, predicted molecular weight of 42 kD. Contains a HMG box DNA binding domain and a CTNNB1 (β-catenin) binding domain.
Distribution: Nucleus
Function: TCF1 is a transcription factor, involved in the canonical Wingless/Integration 1 (Wnt) signaling pathway. TCF1 is essential for survival of CD4+CD8+ double positive thymocytes and differentiation of T cells in the periphery.
Interaction: TCF1 interacts with CTNNB1, TLE1, TLE2, TLE3, TLE4, and AES.
Cell Type: Tregs
Biology Area: Cell Biology, Immunology, Transcription Factors
Molecular Family: Nuclear Markers, TCRs
Antigen References: 1. Mao CD, et al. 2011. Crit. Rev. Eukaryot. Gene Expr. 21:207.
2. Germar K, et al. 2011. P. Natl. Acad. Sci. USA 108:20060.
3. Wang R, et al. 2011. J. Immunol. 187:5964.
4. Weber BN, et al. 2011. Nature 476:63.
5. Jeannet G, et al. 2010. P. Natl. Acad. Sci. USA 107:9777.
6. Staal FJ, et al. 1999. Int. Immunol. 11:317.
Gene ID: 6932 View all products for this Gene ID
UniProt: View information about TCF1 on UniProt.org

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